Objectives: To evaluate maternal and perinatal outcomes of pregnant women affected by SARS-COV-2. Methods: This was a multinational retrospective cohort study including women with laboratory-confirmed SARS-COV-2 from 73 centers from 22 different countries in Europe, United States, South America, Asia and Australia from February 1, 2020 to April 30, 2020. Confirmed SARS-COV-2 infection was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity including admission to intensive care unit (ICU), use of mechanical ventilation, or death. Results: 388 singleton pregnancies tested positive to SARS-COV-2 at RT-PCR nasal and pharyngeal swab were included in the study. The primary outcome was observed in 47/388 women (12.1%). 43/388 women (11.1%) were admitted to ICU, 36/388 (9.3%) required mechanical ventilation, and 3/388 women deceased (0.8%). Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of the study. Among the other 266 women, 6 had spontaneous first-trimester abortion, 3 had elective termination of pregnancy, 6 had stillbirth, and 251 delivered a live-born infant. The rate of preterm birth less than 37 weeks of gestation was 26.3% (70/266). Of the 251 live-born infants, 69/251 (27.5%) were admitted to NICU, with 5 neonatal deaths (2.0%). The overall rate of perinatal death was 4.1% (11/266). Only one infant (1/251, 0.4%) born from a mother tested positive during the third trimester, was found positive to SARS-COV-2 at RT-PCR. Conclusions: SARS-COV-2 in pregnant women is associated with 0.8% rate of maternal mortality, but 11.1% rate of admission to ICU. The risk of vertical transmission seems to be negligible. This article is protected by copyright. All rights reserved.
Maternal and perinatal outcomes of pregnant women with SARS-COV-2 infection / Saccone, Gabriele; Sen, Cihat; Di Mascio, Daniele; Galindo, Alberto; Grünebaum, Amos; Yoshimatsu, Jun; Stanojevic, Milan; Kurjak, Asım; Chervenak, Frank; José Rodríguez Suárez, María; Maria Gambacorti-Passerini, Zita; de los Angeles Anaya Baz, María; Vanessa Aguilar Galán, Esther; Cuñarro López, Yolanda; Antonio De León Luis, Juan; Cueto Hernández, Ignacio; Herraiz, Ignacio; Villalain, Cecilia; Venturella, Roberta; Rizzo, Giuseppe; Mappa, Ilenia; Gerosolima, Giovanni; Hellmeyer, Lars; Königbauer, Josefine; Ameli, Giada; Frusca, Tiziana; Volpe, Nicola; Battista Luca Schera, Giovanni; Fieni, Stefania; Esposito, Eutalia; Simonazzi, Giuliana; Di Donna, Gaetana; Youssef MD, Aly; Nunzia Della Gatta, Anna; Catello Di Donna, Mariano; Chiantera, Vito; Buono, Natalina; Sozzi, Giulio; Greco, Pantaleo; Morano, Danila; Bianchi, Beatrice; Giulia Lombana Marino, Maria; Laraud, Federica; Ramone, Arianna; Cagnacci, Angelo; Barra, Fabio; Gustavino, Claudio; Ferrero, Simone; Ghezzi, Fabio; Cromi, Antonella; Simone Laganà, Antonio; Laurita Longo, Valentina; Stollagli, Francesca; Sirico, Angelo; Lanzone, Antonio; Driul, Lorenza; Cecchini, Fabiana; Xodo, Serena; Rodriguez, Brian; Mercado-Olivares, Felipe; Elkafrawi, Deena; Sisti, Giovanni; Esposito, Rosanna; Coviello, Antonio; Cerbone, Marco; Morlando, Maddalena; Schiattarella, Antonio; Colacurci, Nicola; De Franciscis, Pasquale; Cataneo, Ilaria; Lenzi, Marinella; Sandri, Fabrizio; Buscemi, Riccardo; Gattei, Giorgia; della Sala, Francesca; Valori, Eleonora; Cristina Rovellotti, Maria; Done, Elisa; Faron, Gilles; Gucciardo, Leonardo; Esposito, Valentina; Vena, Flaminia; Giancotti, Antonella; Brunelli, Roberto; Muzii, Ludovico; Nappi, Luigi; Sorrentino, Felice; Liberati, Marco; Buca, Danilo; Leombroni, Martina; Di Sebastiano, Francesca; Franchi, Massimo; Cesare Ianniciello, Quintino; Garzon, Simone; Petriglia, Giuliano; Borrello, Leonardo; Josè Nieto-Calvache, Albaro; Manuel Burgos-Luna, Juan; Kadji, Caroline; Carlin, Andrew; Bevilacqua, Elisa; Moucho, Marina; Viana Pinto, Pedro; Figueiredo, Rita; Morales Roselló, José; Loscalzo, Gabriela; Martinez-Varea, Alicia; Diago, Vincente; S Jimenez Lopez, Jesús; Yeliz Aykanat, Alicia; Cosma, Stefano; Carosso, Andrea; Benedetto, Chiara; Bermejo, Amanda; Henrique May Feuerschuette, Otto; Uyaniklar, Ozlem; Rahimli Ocakouglu, Sakine; Atak, Zeliha; Gündüz, Reyhan; Tustas Haberal, Esra; Froessler, Bernd; Parange, Anupam; Palm, Peter; Samardjiski, Igor; Taccaliti, Chiara; Okuyan, Erhan; Daskalakis, George; Augusto Moreira de Sa, Renato; Pittaro, Alejandro; Luisa Gonzalez-Duran, Maria; Concheiro Guisan, Ana; Özlem Genç, Şerife; Zlatohlávková, Blanka; Luengo Piqueras, Anna; Esteban Oliva, Dolores; Pelin Cil, Aylin; Api, Olus; Antsaklis, Panos; Ples, Liana; Kyvernitakis, Ioannis; Maul, Holger; Malan, Marcel; Lila, Albert; Granese, Roberta; Ercoli, Alfredo; Zoccali, Giuseppe; Villasco, Andrea; Biglia, Nicoletta; Madalina, Ciuhodaru; Costa, Elena; Daelemans, Caroline; Pintiaux, Axelle; Cueto, Elisa; Hadar, Eran; Dollinger, Sarah; Brzezinski-Sinai, Noa A.; Huertas, Erasmo; Arango, Pedro; Sanchez, Amadeo; Alfonso Schvartzman, Javier; Cojocaru, Liviu; Turan, Sifa; Turan, Ozhan; Carmela Di Dedda, Maria; Garrote Molpeceres, Rebeca; Zdjelar, Snezana; Premru-Srsen, Tanja; Kornhauser-Cerar, Lilijana; Druškovič, Mirjam; De Robertis, Valentina; Stefanovic, Vedran; Nupponen, Irmeli; Nelskylä, Kaisa; Khodjaeva, Zulfiya; Gorina, Ksenia A.; Sukhikh, Gennady T.; Maria Maruotti, Giuseppe; Visentin, Silvia; Cosmi, Erich; Ferrari, Jacopo; Gatti, Alessandra; Luvero, Daniela; Angioli, Roberto; Puri, Ludovica; Palumbo, Marco; D’Urso, Giusella; Colaleo, Francesco; Maria Chiara Rapisarda, Agnese; Floriana Carbone, Ilma; Manzoli, Lamberto; Elena Flacco, Maria; Nazzaro, Giovanni; Locci, Mariavittoria; Guida, Maurizio; Di Spiezio Sardo, Attilio; Benedetti Panici, Pierluigi; Khalil, Asma; Berghella, Vincenzo; Bifulco, Giuseppe; Scambia, Giovanni; Zullo, Fulvio; D’Antonio, Francesco. - In: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. - ISSN 0960-7692. - 57:2(2020), pp. 232-241. [10.1002/uog.23107]
Maternal and perinatal outcomes of pregnant women with SARS-COV-2 infection
Daniele Di Mascio
;Flaminia Vena;Antonella Giancotti;Roberto Brunelli;Ludovico Muzii;Pierluigi Benedetti Panici;
2020
Abstract
Objectives: To evaluate maternal and perinatal outcomes of pregnant women affected by SARS-COV-2. Methods: This was a multinational retrospective cohort study including women with laboratory-confirmed SARS-COV-2 from 73 centers from 22 different countries in Europe, United States, South America, Asia and Australia from February 1, 2020 to April 30, 2020. Confirmed SARS-COV-2 infection was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity including admission to intensive care unit (ICU), use of mechanical ventilation, or death. Results: 388 singleton pregnancies tested positive to SARS-COV-2 at RT-PCR nasal and pharyngeal swab were included in the study. The primary outcome was observed in 47/388 women (12.1%). 43/388 women (11.1%) were admitted to ICU, 36/388 (9.3%) required mechanical ventilation, and 3/388 women deceased (0.8%). Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of the study. Among the other 266 women, 6 had spontaneous first-trimester abortion, 3 had elective termination of pregnancy, 6 had stillbirth, and 251 delivered a live-born infant. The rate of preterm birth less than 37 weeks of gestation was 26.3% (70/266). Of the 251 live-born infants, 69/251 (27.5%) were admitted to NICU, with 5 neonatal deaths (2.0%). The overall rate of perinatal death was 4.1% (11/266). Only one infant (1/251, 0.4%) born from a mother tested positive during the third trimester, was found positive to SARS-COV-2 at RT-PCR. Conclusions: SARS-COV-2 in pregnant women is associated with 0.8% rate of maternal mortality, but 11.1% rate of admission to ICU. The risk of vertical transmission seems to be negligible. This article is protected by copyright. All rights reserved.| File | Dimensione | Formato | |
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